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          Cloned monkeys shed light on circadian disorders

          By ZHOU WENTING | China Daily | Updated: 2019-01-24 07:59
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          Zhang Hongjun, a researcher of the Institute of Neuroscience of Chinese Academy of Sciences, introduces relative research achievements about the cloned monkeys at a press conference in Shanghai, east China, Jan 23, 2019. China has cloned five monkeys from a gene-edited macaque with circadian rhythm disorders, the first time multiple monkeys have been cloned from a gene-edited monkey for biomedical research. Scientists made the announcement Thursday, with two articles published in National Science Review, a top Chinese journal in English. The cloned monkeys were born in Shanghai at Institute of Neuroscience of Chinese Academy of Sciences.[Photo/Xinhua]

          The experiment may bring insights into the study of the disease and the invention of therapeutic treatments, according to project researchers at the CAS neuroscience institute.

          The new monkeys have shown a wide range of negative behavior including reduced sleep, elevated nighttime locomotive activities and dampened cycling of blood hormones. They also exhibit elevated anxiety, depression and schizophrenia-like behaviors.

          The experiment paves the way for the study of circadian disorder-related conditions in humans, according to Hung-chun Chang, the leader of the research.

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