Scientists develop nanoparticle system for bone cancer treatment

U.S. researchers said Monday they have developed a drug-delivery system based on nanoparticles that can precisely target and attack cancer cells in the bone to fight bone cancer.

The system, developed through a research collaboration between Brigham and Women's Hospital (BWH) and Dana-Farber Cancer Institute (DFCI), can also increase bone strength and volume to prevent bone cancer progression.

"There are limited treatment options for bone cancers," co-lead study author Michaela Reagan of DFCI Center for Hematologic Oncology said in a statement. "Our engineered targeted therapies manipulate the tumor cells in the bone and the surrounding microenvironment to effectively prevent cancer from spreading in bone with minimal off-target effects."

According to the researchers, the nanoparticle system is made of a combination of biodegradable polymers and alendronate, a therapeutic agent, which belongs to the bisphosphonate class of drugs.

Bisphosphonates bind to calcium and the largest store of calcium in the human body is in bones, so bisphosphonates accumulate in high concentration in bones, they said.

"Bone is a favorable microenvironment for the growth of cancer cells that migrate from tumors in distant organs of the body, such as breast, prostate and blood, during disease progression," said co-lead study author Archana Swami of BWH Laboratory of Nanomedicine and Biomaterials.

"We engineered and tested a bone-targeted nanoparticle system to selectively target the bone microenvironment and release a therapeutic drug in a spatiotemporally controlled manner, leading to bone microenvironment remodeling and prevention of disease progression."